Complex

Complex Type Analog Binding affinity (kcal/mol) -4.56281
Original complex ADP-921 Predicted complex ATP
Interaction Residues
N_532_ASP N_533_LEU N_534_GLY N_535_GLY
N_536_ALA N_537_ASN N_539_ARG N_601_THR
N_603_SER N_621_LYS N_657_ASP N_661_THR
N_676_LEU N_677_ILE N_678_VAL N_679_GLY
N_680_THR N_681_GLY N_682_SER N_746_SER
N_747_GLY N_748_MET N_749_TYR N_750_LEU
N_783_GLU N_784_THR N_785_LYS N_786_PHE
N_787_LEU N_788_SER N_789_GLN N_861_ASP
N_862_GLY N_863_THR N_864_LEU N_865_TYR
N_866_LYS N_867_LEU N_868_HIS N_869_PRO
N_896_GLY N_897_SER N_898_GLY
Variants
Residue Variant
AA UniProtKB/
Swiss-prot		 dbSNP Type
 Disease name
N_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_776_LEU MET rs1054203 Polymorphism -
N_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
Phosphosites
Residue Data source
N_27_TYR PhosphoSitePlus
N_124_SER PhosphoSitePlus
N_364_SER PhosphoSitePlus
N_417_TYR PhosphoSitePlus
N_732_TYR PhosphoSitePlus
Reaction
KEGG ID R00760 
Name ATP:D-fructose 6-phosphotransferase
Definition ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate
Equation ATP + {FRU, Z9N} <=> ADP + {F6P, P6P}
+ <=> +
Pathway
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Molecular Description
PDB ID 1dgk 
Classification Transferase
Name HEXOKINASE TYPE I
Synonym HK I, BRAIN FORM HEXOKINASE
Chain N
EC# 2.7.1.1 
Organism homo sapiens
UniProtKB P19367 
Ligand Chemical Component
PDB CCD ATP
Name ADENOSINE-5'-TRIPHOSPHATE
KEGG ID C00002 
Formula C10H16N5O13P3
PubChem 3304
Analogous
compounds		 0OH, 0OJ, 3AT, 5FA, 8DG, ACP, AD9, ADI, ADP, AGS, AN2, ANP, AOV, AQP, CH1, CTP, DAD, DAT, DCP, DCT, DDS, DG3, DGT, DTP, DUT, GDP, GH3, GTP, LA8, ONA, STP, TAT, TTP, UTP