|
|
Complex
| Complex Type | Analog | Binding affinity (kcal/mol) | -4.16314 |
|---|---|---|---|
| Original complex | ANP-999 | Predicted complex | ATP |
Interaction Residues
| A_19_VAL | A_23_ASP | A_26_LEU | A_27_TYR | ||||
| A_29_MET | A_30_ARG | A_31_LEU | A_32_SER | ||||
| A_33_ASP | A_36_LEU | A_343_GLU | A_345_ASN | ||||
| A_372_GLN | A_373_HIS | A_376_THR | A_377_ILE | ||||
| A_378_VAL | A_380_PHE | A_381_ARG | A_384_ASN | ||||
| A_422_GLN | A_425_ARG | A_426_ARG | A_429_LYS | ||||
| A_433_ARG | |||||||
Variants
| Residue | Variant | |||||
|---|---|---|---|---|---|---|
| AA | UniProtKB/ Swiss-prot |
dbSNP |
Type |
Disease name | ||
| A_529_LEU | SER |
|
rs137853249 | Disease | Hexokinase deficiency (HK deficiency) [MIM:235700] | |
| A_680_THR | SER |
|
rs398122379 | Disease | Hexokinase deficiency (HK deficiency) [MIM:235700] | |
| A_776_LEU | MET |
|
rs1054203 | Polymorphism | - | |
| A_847_GLU | LYS |
|
rs777849213 | Unclassified | Retinitis pigmentosa 79 (RP79) [MIM:617460] | |
| B_529_LEU | SER |
|
rs137853249 | Disease | Hexokinase deficiency (HK deficiency) [MIM:235700] | |
| B_680_THR | SER |
|
rs398122379 | Disease | Hexokinase deficiency (HK deficiency) [MIM:235700] | |
| B_776_LEU | MET |
|
rs1054203 | Polymorphism | - | |
| B_847_GLU | LYS |
|
rs777849213 | Unclassified | Retinitis pigmentosa 79 (RP79) [MIM:617460] | |
Phosphosites
| Residue | Data source | |
|---|---|---|
| A_27_TYR | PhosphoSitePlus | |
| A_124_SER | PhosphoSitePlus | |
| A_364_SER | PhosphoSitePlus | |
| A_417_TYR | PhosphoSitePlus | |
| A_732_TYR | PhosphoSitePlus | |
| B_27_TYR | PhosphoSitePlus | |
| B_124_SER | PhosphoSitePlus | |
| B_364_SER | PhosphoSitePlus | |
| B_417_TYR | PhosphoSitePlus | |
| B_732_TYR | PhosphoSitePlus |
Reaction
| KEGG ID |
R00760
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | ATP:D-fructose 6-phosphotransferase | ||||||||||
| Definition | ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate | ||||||||||
| Equation | ATP + {FRU, Z9N} <=> ADP + {F6P, P6P} | ||||||||||
|
|||||||||||
| Pathway |
|
Molecular Description
| PDB ID |
1qha
|
|---|---|
| Classification | Transferase |
| Name | PROTEIN (HEXOKINASE) |
| Synonym | |
| Chain | A |
| EC# |
2.7.1.1
|
| Organism | homo sapiens |
| UniProtKB |
P19367
|
Ligand Chemical Component
| PDB CCD | ATP |
|---|---|
| Name | ADENOSINE-5'-TRIPHOSPHATE |
| KEGG ID |
C00002
|
| Formula | C10H16N5O13P3 |
| PubChem | 3304 |
| Analogous compounds |
0OH, 0OJ, 3AT, 5FA, 8DG, ACP, AD9, ADI, ADP, AGS, AN2, ANP, AOV, AQP, CH1, CTP, DAD, DAT, DCP, DCT, DDS, DG3, DGT, DTP, DUT, GDP, GH3, GTP, LA8, ONA, STP, TAT, TTP, UTP |
