Complex

Complex Type Analog Binding affinity (kcal/mol) -4.74165
Original complex ADP-922 Predicted complex ATP
Interaction Residues
N_19_VAL N_23_ASP N_26_LEU N_29_MET
N_30_ARG N_31_LEU N_32_SER N_33_ASP
N_36_LEU N_373_HIS N_376_THR N_377_ILE
N_378_VAL N_379_SER N_380_PHE N_381_ARG
N_384_ASN N_422_GLN N_425_ARG N_426_ARG
N_429_LYS N_430_THR N_433_ARG
Variants
Residue Variant
AA UniProtKB/
Swiss-prot		 dbSNP Type
 Disease name
N_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_776_LEU MET rs1054203 Polymorphism -
N_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
Phosphosites
Residue Data source
N_27_TYR PhosphoSitePlus
N_124_SER PhosphoSitePlus
N_364_SER PhosphoSitePlus
N_417_TYR PhosphoSitePlus
N_732_TYR PhosphoSitePlus
Reaction
KEGG ID R00760 
Name ATP:D-fructose 6-phosphotransferase
Definition ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate
Equation ATP + {FRU, Z9N} <=> ADP + {F6P, P6P}
+ <=> +
Pathway
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Molecular Description
PDB ID 1dgk 
Classification Transferase
Name HEXOKINASE TYPE I
Synonym HK I, BRAIN FORM HEXOKINASE
Chain N
EC# 2.7.1.1 
Organism homo sapiens
UniProtKB P19367 
Ligand Chemical Component
PDB CCD ATP
Name ADENOSINE-5'-TRIPHOSPHATE
KEGG ID C00002 
Formula C10H16N5O13P3
PubChem 3304
Analogous
compounds		 0OH, 0OJ, 3AT, 5FA, 8DG, ACP, AD9, ADI, ADP, AGS, AN2, ANP, AOV, AQP, CH1, CTP, DAD, DAT, DCP, DCT, DDS, DG3, DGT, DTP, DUT, GDP, GH3, GTP, LA8, ONA, STP, TAT, TTP, UTP