Complex

Complex Type Natural Binding affinity (kcal/mol) -
Original complex ADP-922 Predicted complex -
Interaction Residues
N_19_VAL N_23_ASP N_29_MET N_30_ARG
N_31_LEU N_32_SER N_33_ASP N_36_LEU
N_343_GLU N_372_GLN N_373_HIS N_376_THR
N_377_ILE N_378_VAL N_379_SER N_380_PHE
N_381_ARG N_384_ASN N_422_GLN N_425_ARG
N_426_ARG N_429_LYS N_433_ARG
Variants
Residue Variant
AA UniProtKB/
Swiss-prot		 dbSNP Type
 Disease name
N_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_776_LEU MET rs1054203 Polymorphism -
N_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
Phosphosites
Residue Data source
N_27_TYR PhosphoSitePlus
N_124_SER PhosphoSitePlus
N_364_SER PhosphoSitePlus
N_417_TYR PhosphoSitePlus
N_732_TYR PhosphoSitePlus
Reaction
KEGG ID R00760 
Name ATP:D-fructose 6-phosphotransferase
Definition ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate
Equation ATP + {FRU, Z9N} <=> ADP + {F6P, P6P}
+ <=> +
Pathway
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Molecular Description
PDB ID 1dgk 
Classification Transferase
Name HEXOKINASE TYPE I
Synonym HK I, BRAIN FORM HEXOKINASE
Chain N
EC# 2.7.1.1 
Organism homo sapiens
UniProtKB P19367 
Ligand Chemical Component
PDB CCD ADP
Name ADENOSINE-5'-DIPHOSPHATE
KEGG ID C00008 
Formula C10H15N5O10P2
PubChem 3310
Analogous
compounds		 08T, 2A5, 3AN, 5GP, A, ABP, ACP, AD9, ADX, AGS, AMP, AN2, ANP, AOV, APR, AQP, AR6, AT4, ATF, ATP, ATR, ATS, AV2, CA0, CDP, D5M, DAT, DGT, DTP, GCP, GDP, GNP, GTP, IMP, LA8, MGP, PAP, UDP