Complex

Complex Type Natural Binding affinity (kcal/mol) -
Original complex ADP-921 Predicted complex -
Interaction Residues
N_532_ASP N_534_GLY N_535_GLY N_536_ALA
N_537_ASN N_538_PHE N_539_ARG N_559_ILE
N_621_LYS N_657_ASP N_677_ILE N_678_VAL
N_679_GLY N_680_THR N_681_GLY N_746_SER
N_747_GLY N_748_MET N_749_TYR N_750_LEU
N_783_GLU N_784_THR N_785_LYS N_786_PHE
N_787_LEU N_788_SER N_789_GLN N_861_ASP
N_862_GLY N_863_THR N_864_LEU N_865_TYR
N_866_LYS N_867_LEU N_868_HIS N_869_PRO
Variants
Residue Variant
AA UniProtKB/
Swiss-prot		 dbSNP Type
 Disease name
N_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_776_LEU MET rs1054203 Polymorphism -
N_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
Phosphosites
Residue Data source
N_27_TYR PhosphoSitePlus
N_124_SER PhosphoSitePlus
N_364_SER PhosphoSitePlus
N_417_TYR PhosphoSitePlus
N_732_TYR PhosphoSitePlus
Reaction
KEGG ID R00760 
Name ATP:D-fructose 6-phosphotransferase
Definition ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate
Equation ATP + {FRU, Z9N} <=> ADP + {F6P, P6P}
+ <=> +
Pathway
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Molecular Description
PDB ID 1dgk 
Classification Transferase
Name HEXOKINASE TYPE I
Synonym HK I, BRAIN FORM HEXOKINASE
Chain N
EC# 2.7.1.1 
Organism homo sapiens
UniProtKB P19367 
Ligand Chemical Component
PDB CCD ADP
Name ADENOSINE-5'-DIPHOSPHATE
KEGG ID C00008 
Formula C10H15N5O10P2
PubChem 3310
Analogous
compounds		 08T, 2A5, 3AN, 5GP, A, ABP, ACP, AD9, ADX, AGS, AMP, AN2, ANP, AOV, APR, AQP, AR6, AT4, ATF, ATP, ATR, ATS, AV2, CA0, CDP, D5M, DAT, DGT, DTP, GCP, GDP, GNP, GTP, IMP, LA8, MGP, PAP, UDP