Complex

Complex Type Analog Binding affinity (kcal/mol) -4.43974
Original complex ANP-1999 Predicted complex ATP
Interaction Residues
B_19_VAL B_20_LYS B_23_ASP B_26_LEU
B_29_MET B_30_ARG B_31_LEU B_32_SER
B_33_ASP B_36_LEU B_372_GLN B_373_HIS
B_376_THR B_377_ILE B_378_VAL B_379_SER
B_380_PHE B_381_ARG B_384_ASN B_425_ARG
B_426_ARG B_429_LYS B_433_ARG
Variants
Residue Variant
AA UniProtKB/
Swiss-prot
dbSNP Type
Disease name
A_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
A_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
A_776_LEU MET rs1054203 Polymorphism -
A_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
B_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
B_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
B_776_LEU MET rs1054203 Polymorphism -
B_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
Phosphosites
Residue Data source
A_27_TYR PhosphoSitePlus
A_124_SER PhosphoSitePlus
A_364_SER PhosphoSitePlus
A_417_TYR PhosphoSitePlus
A_732_TYR PhosphoSitePlus
B_27_TYR PhosphoSitePlus
B_124_SER PhosphoSitePlus
B_364_SER PhosphoSitePlus
B_417_TYR PhosphoSitePlus
B_732_TYR PhosphoSitePlus
Reaction
KEGG ID R00760 
Name ATP:D-fructose 6-phosphotransferase
Definition ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate
Equation ATP + FRU <=> ADP + {F6P, P6P}
+ <=> +
Pathway
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Molecular Description
PDB ID 1qha 
Classification Transferase
Name PROTEIN (HEXOKINASE)
Synonym
Chain B
EC# 2.7.1.1 
Organism homo sapiens
UniProtKB P19367 
Ligand Chemical Component
PDB CCD ATP
Name ADENOSINE-5'-TRIPHOSPHATE
KEGG ID C00002 
Formula C10H16N5O13P3
PubChem 3304
Analogous
compounds
0OH, 0OJ, 3AT, 5FA, 8DG, ACP, AD9, ADI, ADP, AGS, AN2, ANP, AOV, AQP, CH1, CTP, DAD, DAT, DCP, DCT, DDS, DG3, DGT, DTP, DUT, GDP, GH3, GTP, LA8, ONA, STP, TAT, TTP, UTP