Complex

Complex Type Analog Binding affinity (kcal/mol) -4.43974
Original complex ANP-1999 Predicted complex ATP
Interaction Residues
B_19_VAL B_20_LYS B_23_ASP B_26_LEU
B_29_MET B_30_ARG B_31_LEU B_32_SER
B_33_ASP B_36_LEU B_372_GLN B_373_HIS
B_376_THR B_377_ILE B_378_VAL B_379_SER
B_380_PHE B_381_ARG B_384_ASN B_425_ARG
B_426_ARG B_429_LYS B_433_ARG
Variants
Residue Variant
AA UniProtKB/
Swiss-prot
dbSNP Type
Disease name
A_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
A_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
A_776_LEU MET rs1054203 Polymorphism -
A_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
B_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
B_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
B_776_LEU MET rs1054203 Polymorphism -
B_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
Phosphosites
Residue Data source
A_27_TYR PhosphoSitePlus
A_124_SER PhosphoSitePlus
A_364_SER PhosphoSitePlus
A_417_TYR PhosphoSitePlus
A_732_TYR PhosphoSitePlus
B_27_TYR PhosphoSitePlus
B_124_SER PhosphoSitePlus
B_364_SER PhosphoSitePlus
B_417_TYR PhosphoSitePlus
B_732_TYR PhosphoSitePlus
Reaction
KEGG ID R00760 
Name ATP:D-fructose 6-phosphotransferase
Definition ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate
Equation ATP + FRU <=> ADP + {F6P, P6P}
+ <=> +
Pathway
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Molecular Description
PDB ID 1qha 
Classification Transferase
Name PROTEIN (HEXOKINASE)
Synonym
Chain B
EC# 2.7.1.1 
Organism homo sapiens
UniProtKB P19367 
Ligand Chemical Component
PDB CCD ATP
Name ADENOSINE-5'-TRIPHOSPHATE
KEGG ID C00002 
Formula C10H16N5O13P3
PubChem 3304