Complex

Complex Type Analog Binding affinity (kcal/mol) -4.16314
Original complex ANP-999 Predicted complex ATP
Interaction Residues
A_19_VAL A_23_ASP A_26_LEU A_27_TYR
A_29_MET A_30_ARG A_31_LEU A_32_SER
A_33_ASP A_36_LEU A_343_GLU A_345_ASN
A_372_GLN A_373_HIS A_376_THR A_377_ILE
A_378_VAL A_380_PHE A_381_ARG A_384_ASN
A_422_GLN A_425_ARG A_426_ARG A_429_LYS
A_433_ARG
Variants
Residue Variant
AA UniProtKB/
Swiss-prot
dbSNP Type
Disease name
A_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
A_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
A_776_LEU MET rs1054203 Polymorphism -
A_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
B_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
B_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
B_776_LEU MET rs1054203 Polymorphism -
B_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
Phosphosites
Residue Data source
A_27_TYR PhosphoSitePlus
A_124_SER PhosphoSitePlus
A_364_SER PhosphoSitePlus
A_417_TYR PhosphoSitePlus
A_732_TYR PhosphoSitePlus
B_27_TYR PhosphoSitePlus
B_124_SER PhosphoSitePlus
B_364_SER PhosphoSitePlus
B_417_TYR PhosphoSitePlus
B_732_TYR PhosphoSitePlus
Reaction
KEGG ID R00760 
Name ATP:D-fructose 6-phosphotransferase
Definition ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate
Equation ATP + FRU <=> ADP + {F6P, P6P}
+ <=> +
Pathway
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Molecular Description
PDB ID 1qha 
Classification Transferase
Name PROTEIN (HEXOKINASE)
Synonym
Chain A
EC# 2.7.1.1 
Organism homo sapiens
UniProtKB P19367 
Ligand Chemical Component
PDB CCD ATP
Name ADENOSINE-5'-TRIPHOSPHATE
KEGG ID C00002 
Formula C10H16N5O13P3
PubChem 3304