Complex

Complex Type Analog Binding affinity (kcal/mol) -4.16314
Original complex ANP-999 Predicted complex ATP
Interaction Residues
A_19_VAL A_23_ASP A_26_LEU A_27_TYR
A_29_MET A_30_ARG A_31_LEU A_32_SER
A_33_ASP A_36_LEU A_343_GLU A_345_ASN
A_372_GLN A_373_HIS A_376_THR A_377_ILE
A_378_VAL A_380_PHE A_381_ARG A_384_ASN
A_422_GLN A_425_ARG A_426_ARG A_429_LYS
A_433_ARG
Variants
Residue Variant
AA UniProtKB/
Swiss-prot
dbSNP Type
Disease name
A_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
A_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
A_776_LEU MET rs1054203 Polymorphism -
A_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
B_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
B_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
B_776_LEU MET rs1054203 Polymorphism -
B_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
Phosphosites
Residue Data source
A_27_TYR PhosphoSitePlus
A_124_SER PhosphoSitePlus
A_364_SER PhosphoSitePlus
A_417_TYR PhosphoSitePlus
A_732_TYR PhosphoSitePlus
B_27_TYR PhosphoSitePlus
B_124_SER PhosphoSitePlus
B_364_SER PhosphoSitePlus
B_417_TYR PhosphoSitePlus
B_732_TYR PhosphoSitePlus
Reaction
KEGG ID R00760 
Name ATP:D-fructose 6-phosphotransferase
Definition ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate
Equation ATP + FRU <=> ADP + {F6P, P6P}
+ <=> +
Pathway
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Molecular Description
PDB ID 1qha 
Classification Transferase
Name PROTEIN (HEXOKINASE)
Synonym
Chain A
EC# 2.7.1.1 
Organism homo sapiens
UniProtKB P19367 
Ligand Chemical Component
PDB CCD ATP
Name ADENOSINE-5'-TRIPHOSPHATE
KEGG ID C00002 
Formula C10H16N5O13P3
PubChem 3304
Analogous
compounds
0OH, 0OJ, 3AT, 5FA, 8DG, ACP, AD9, ADI, ADP, AGS, AN2, ANP, AOV, AQP, CH1, CTP, DAD, DAT, DCP, DCT, DDS, DG3, DGT, DTP, DUT, GDP, GH3, GTP, LA8, ONA, STP, TAT, TTP, UTP