Complex

Complex Type Analog Binding affinity (kcal/mol) -4.56281
Original complex ADP-921 Predicted complex ATP
Interaction Residues
N_532_ASP N_533_LEU N_534_GLY N_535_GLY
N_536_ALA N_537_ASN N_539_ARG N_601_THR
N_603_SER N_621_LYS N_657_ASP N_661_THR
N_676_LEU N_677_ILE N_678_VAL N_679_GLY
N_680_THR N_681_GLY N_682_SER N_746_SER
N_747_GLY N_748_MET N_749_TYR N_750_LEU
N_783_GLU N_784_THR N_785_LYS N_786_PHE
N_787_LEU N_788_SER N_789_GLN N_861_ASP
N_862_GLY N_863_THR N_864_LEU N_865_TYR
N_866_LYS N_867_LEU N_868_HIS N_869_PRO
N_896_GLY N_897_SER N_898_GLY
Variants
Residue Variant
AA UniProtKB/
Swiss-prot
dbSNP Type
Disease name
N_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_776_LEU MET rs1054203 Polymorphism -
N_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
Reaction
KEGG ID R00760 
Name ATP:D-fructose 6-phosphotransferase
Definition ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate
Equation ATP + FRU <=> ADP + {F6P, P6P}
+ <=> +
Pathway
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Molecular Description
PDB ID 1dgk 
Classification Transferase
Name HEXOKINASE TYPE I
Synonym HK I, BRAIN FORM HEXOKINASE
Chain N
EC# 2.7.1.1 
Organism homo sapiens
UniProtKB P19367 
Ligand Chemical Component
PDB CCD ATP
Name ADENOSINE-5'-TRIPHOSPHATE
KEGG ID C00002 
Formula C10H16N5O13P3
PubChem 3304