Complex

Complex Type Analog Binding affinity (kcal/mol) -4.82852
Original complex ADP-922 Predicted complex ATP
Interaction Residues
N_19_VAL N_23_ASP N_26_LEU N_29_MET
N_30_ARG N_31_LEU N_32_SER N_33_ASP
N_36_LEU N_373_HIS N_376_THR N_377_ILE
N_378_VAL N_379_SER N_380_PHE N_381_ARG
N_384_ASN N_422_GLN N_425_ARG N_426_ARG
N_429_LYS N_430_THR N_433_ARG
Variants
Residue Variant
AA UniProtKB/
Swiss-prot
dbSNP Type
Disease name
N_529_LEU SER rs137853249 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_680_THR SER rs398122379 Disease Hexokinase deficiency (HK deficiency) [MIM:235700]
N_776_LEU MET rs1054203 Polymorphism -
N_847_GLU LYS rs777849213 Unclassified Retinitis pigmentosa 79 (RP79) [MIM:617460]
Phosphosites
Residue Data source
N_27_TYR PhosphoSitePlus
N_124_SER PhosphoSitePlus
N_364_SER PhosphoSitePlus
N_417_TYR PhosphoSitePlus
N_732_TYR PhosphoSitePlus
Reaction
KEGG ID R00760 
Name ATP:D-fructose 6-phosphotransferase
Definition ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate
Equation ATP + FRU <=> ADP + {F6P, P6P}
+ <=> +
Pathway
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Molecular Description
PDB ID 1cza 
Classification Transferase
Name HEXOKINASE TYPE I
Synonym
Chain N
EC# 2.7.1.1 
Organism homo sapiens
UniProtKB P19367 
Ligand Chemical Component
PDB CCD ATP
Name ADENOSINE-5'-TRIPHOSPHATE
KEGG ID C00002 
Formula C10H16N5O13P3
PubChem 3304